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KMID : 0374019940170030197
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Ewha Medical Journal
1994 Volume.17 No. 3 p.197 ~ p.204
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Prevalence of Antibody to Hepatitis C Virus(antiHCV) with Detection of HCV-RNA by Polymerase Chain Reaction(PCR) in End Stage Renal Disease Patients on Hemodialysis
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Abstract
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patients undergoing maintenance hemodialysis(HD) potentially have an increased risk of exposure to viral hepatitis. The reported prevalence of antiHCV in hemodialysis patients varied widely form 7.6-54% according to dialysis center and there were
many
reports that showed the correlation between the prevalence of antiHCV and duration of HD or transfusion amount.
Fifty-four patients on regular hemodialysis at our hospital were evaluated for the presence of hepatitic C antibody(antiHCV) with the comparison of various parameters such as duration of HD, amount of transfusion, AntiHCV using second-generation
enzyme
linked immunosorbant assay were found in six of 54 HD patients (11.1%). Among six antiHCV(+) patients, four patients were found to have HCV-RNA in their plasma detected by PCR. The percent of male patients were significantly higher in antiHCV(+)
group
(66.7 vs. 31.3%, P<0.05). The positivity of anti-HCV did not correlated with the duration of HD and amount of transfusion (P>0.05), but there was significant correlation with inceased alanine aminotransferase(P<0.05). While the prevalence
increased
over
2 years(5.9% in 1991. 11.1% in 1993) and HBsAg prevalence remained unchanged(9.8% in 1991, 9.3% in 1993).
Therefore, regular follow-up of liver function test and use of separate machine for antiHCV positive patients may be needed to prevent the transmission of hepatitis C virus during the hemodialysis proses itself.
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KEYWORD
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